CONFIDENCE trial: Recruiting international centers
We are thrilled to announce that the CONFIDENCE trial has now received approval to include centers from outside the Netherlands! Please contact us if you are interested in joining the study.
Read morePRoFLUID has started!
On April 1st of 2024, the first 2 countries (with over 20 ICU's) have started the inclusion period for the PRoFLUID. Over 150 patients have been included already!
Read moreBIG APPLE is looking for participating centers
The BIG APPLE study has started recruiting patients and is looking for participating centers in the Netherlands and beyond. Interested? Contact us at bigapple@amsterdamumc.nl or use the contact form below!
Read moreGENERATOR is looking for participating centers
The GENERATOR study has started recruiting patients in multiple centers and is looking for participating centers in the Netherlands and beyond. Interested? Contact us at generator@amsterdamumc.nl or use the contact form below!
Read more500 patients included in the CONFIDENCE trial!
Over 500 patients have now been included in the trial! This means we have included half of our target sample size.
Read moreGENERATOR study looking for participating centers
The GENERATOR study received ethical approval in the Netherlands and will start patient recruitment in the Amsterdam UMC in November 2023. We are looking for Dutch and international centers to join the team. This trial is conducted and coordinated by the PROVEnetwork.
Read moreGENERATOR Ethical approval institutional review board
The GENERATOR project has received ethical approval from the institutional review board of the Amsterdam University Medical Centers. The first patient is expected to be enrolled in November 2023
Read moreSecond steering committee meeting - September 27th
The second steering committee meeting took place on Wednesday September 27th. We shared the results of the pilot studies and discussed the upcoming steps. Please find the presentation below, under the header 'documents'.
Read moreSecond steering committee meeting on September 27th
The second PRoVENT-PED steering committee meeting will take place on Wednesday September 27th, to share the results of the pilot studies and to discuss the upcoming steps.
Read morePRoVENT-PED has started.
We are currently performing the pilot studies for feasibility in two Dutch hospitals: the Amsterdam University Medical Center (AUMC) and the University Medical Center of Groningen (UMCG). Furthermore, we started with recruiting centers, national coordinators and local coordinators who are interested in participating.
Read moreThe PRoVENT-PED protocol has been approved by the Institutional Review Board.
The PRoVENT-PED protocol has been approved by the Institutional Review Board in July 2023.
Read more200 CONFIDENCE patients included
200 patients have been included in the CONFIDENCE trial! With the start of new centers, inclusion rate is increasing rapidly.
Read morePRoFLUID pilot study concluded
A local pilot has been done for the PRoFLUID. The pilot included 45 invasively ventilated patients from the Amsterdam UMC during a 28 day inclusion period.
Read morePRoFLUID registered on clinicaltrials.gov
PRoFLUID has been registered on clinicaltrials.gov
Read morePRoVENT-PED is in preparation
PRoVENT-PED is in preparation! In July 2023 we got the protocol approved by the METC.
Read morePublication of the CONFIDENCE trial protocol
The trial protocol has been published with open access in BioMedCentral Trials.
Read moreHappy 2023!
Happy 2023 from the PEGASUS study team. We've started the new year with ethics approval in the Netherlands, Poland, Italy, Portugal, Denmark and Belgium! Early this year many centres in these countries will start patient inclusion. Based on the experience of the first 8 patients we included in Amsterdam, we are writing a detailed handbook on how to guide mechanical ventilation in PEGASUS patients.
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