Studies
Get an overview of our studies and discover opportunities to collaborate
News
Find out the latest news about our studies and developments in our research group
Who we are
Get to know us!
About Intensive Care Research in the Amsterdam UMC
The ICU research group of the Amsterdam UMC in the Netherlands is focused on conducting innovative high quality research on various topics, including but not limited to ARDS, sepsis, post-anoxic brain injury, machine learning, mechanical ventilation and lung ultrasound. To obtain this goal we combine preclinical research in the laboratory of experimental intensive care and anesthesiology (LEICA), clinical studies ranging from observational cohort studies, to diagnostic accuracy studies and randomized controlled trial and data from large registries.
Our studies
-
Design: Multicenter International RCT
-
Patients: 538 patients with moderate to severe ARDS
-
Intervention: Lung ultrasound guided personalized ventilation
-
Principal Investigator: Lieuwe D.J. Bos
-
Status: Recruiting and looking for centers
-
Design: Multicenter RCT
-
Patients: 1000 patients receiving invasive ventilation >24 h
-
Intervention: Lung ultrasound guided deresuscitation
-
Principal Investigator: Marcus J. Schultz
-
Status: Recruiting completed
-
Design: Prospective International Multinational Observational Cohort Study
-
Patients: Critically ill pediatric patients necessitating ventilatory support > 12 hours
-
Aim: To describe the worldwide practice of ventilatory support in critically ill pediatric patients
-
Principal Investigator: Martin C. J. Kneyber
-
Status: Completed
-
Design: Multicenter double blind international randomized clinical trial
-
Patients: 1806 patients scheduled for major minimally invasive abdominal surgery
-
Intervention: Individualized high PEEP strategy with recruitment maneuvers
-
Principal Investigator: Markus W. Hollmann
-
Status: Recruiting and looking for centers
Current Practice of Ventilation Strategies in Children undergoing General Anesthesia and Associations with Postoperative Pulmonary Complications
-
Design: Multicenter international observational cohort study
-
Patients: Pediatric patients undergoing invasive ventilation in the operating room
-
Principal Investigator: Jorinde Polderman en David van Meenen
-
Status: Data collection is closed
-
Design: Nationwide multi-phase implementation study
-
Participants: Dutch ICUs and ICU healthcare professionals
-
Intervention: Consensus-based decision support tool for indication-based nebulization
-
Principal Investigator: Prof. Frederique Paulus
-
Status: Preparation phase – implementation setup ongoing
-
Platform trial
-
ARDS: stratified into hypo- and hyper-inflammatory
-
Multiple interventions: Baricitinib and Simvastatin
-
Currently recruiting in UK, EU approval pending
News
PEGASUS study half way
The PEGASUS study has reaching 50% of the intended inclusions! Many thanks to all the wonderful collaborators.
The third phase of PRoVENT-PED will be starting soon!
This next phase will focus on patient–ventilator asynchrony, with the inclusion period scheduled to begin in September 2026.
The second phase of PRoVENT-PED has successfully reached its target sample size
A total of 107 hospitals across 40 countries have enrolled 1,500 pediatric patients receiving noninvasive respiratory support, marking the completion of the second phase.
Upcoming
events
Our people
-
Prof. Lieuwe D.J. Bos
Prof. dr. Alexander P.J. Vlaar
Prof. Dr. Pieter Roel Tuinman
Prof. dr. Frederique Paulus
-
Prof. dr. Janneke Horn
Dr. Marry R. Smit
Dr. Laura Buiteman
Dr. Willemke Stilma
-
Dr. Marcella Müller
Dr. Jimmy Schenk
Drs. Jante S. Sinnige
Drs. Siebe Blok
-
Dr. David M.P. van Meenen
Drs. Relin van Vliet
Andrea Esmeijer, MSc, CCRN
Drs. Lina Kramer
-
Dr. Eline Kho
Drs. Atze Bellaar
Drs. Pierette P.C.H. Oomes
Dr. Senta Jorinde Raasveld
Publications
Lung Ultrasound Prediction Model for Acute Respiratory Distress Syndrome: A Multicenter Prospective Observational Study.
Smit MR, Hagens LA, Heijnen NFL, Pisani L, Cherpanath TGV, Dongelmans DA, de Grooth HS, Pierrakos C, Tuinman PR, Zimatore C, Paulus F, Schnabel RM, Schultz MJ, Bergmans DCJJ, Bos LDJ; DARTS Consortium. Lung Ultrasound Prediction Model for Acute Respiratory Distress Syndrome: A Multicenter Prospective Observational Study. Am J Respir Crit Care Med. 2023 Feb 15. doi: 10.1164/rccm.202210-1882OC. Epub ahead of print. PMID: 36790377.
Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes
Bos LDJ, Ware LB. Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes. Lancet. 2022 Oct 1;400(10358):1145-1156. doi: 10.1016/S0140-6736(22)01485-4. Epub 2022 Sep 4. PMID: 36070787.
Lung Ultrasound Assessment of Focal and Non-focal Lung Morphology in Patients With Acute Respiratory Distress Syndrome
Pierrakos C, Smit MR, Pisani L, Paulus F, Schultz MJ, Constantin JM, Chiumello D, Mojoli F, Mongodi S, Bos LDJ. Lung Ultrasound Assessment of Focal and Non-focal Lung Morphology in Patients With Acute Respiratory Distress Syndrome. Front Physiol. 2021 Sep 14;12:730857. doi: 10.3389/fphys.2021.730857. PMID: 34594240; PMCID: PMC8476947.
Immunomodulation and endothelial barrier protection mediate the association between oral imatinib and mortality in hospitalised COVID-19 patients
de Brabander J, Duijvelaar E, Schippers JR, Smeele PJ, Peters-Sengers H, Duitman JW, Aman J, Bogaard HJ, van der Poll T, Bos LDJ; CounterCOVID study group. Immunomodulation and endothelial barrier protection mediate the association between oral imatinib and mortality in hospitalised COVID-19 patients. Eur Respir J. 2022 Jul 26:2200780. doi: 10.1183/13993003.00780-2022. Epub ahead of print. PMID: 35896211; PMCID: PMC9301934.
