Our Focus
Our research focuses on cardiovascular and cerebrovascular physiology in high-risk surgical and critically ill patients. We study hemodynamic physiology using advanced pulse wave analysis and machine learning models to predict instability and optimize perioperative outcomes, with particular expertise in hypotension management in anesthesia and intensive care. Our translational program combines pre-clinical and clinical research on hemodynamic management in critical illness. This includes work on endothelial leakage, microcirculatory alterations during ECMO treatment, and optimization of bedside hemodynamic monitoring. We also examine variation in clinical practice and its impact on patient outcomes.
In addition, we investigate non-invasive quantification of static and dynamic cerebral autoregulation during surgery to improve brain protection during hemodynamic fluctuations. Using continuous blood pressure waveform analysis, we develop tools to enhance diagnosis during hemodynamic instability and enable earlier detection of vascular abnormalities. Beyond research, we emphasize education, implementation, and innovation. Our work promotes evidence-based decision-making, develops new monitoring strategies, and explores nurse-driven approaches to hemodynamic care that enhance autonomy and treatment efficiency.
DYNAMO Team
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Prof. dr. Denise Veelo
Prof. dr. Alexander Vlaar
Dr. Jimmy Schenk
Dr. Rogier Immink
